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Abstract #2126

Age-related differences in CBF, CVR, M, OEF and CMRO2 using MRI QUO2 and dual-echo pCASL

Isabelle Lajoie 1 , Kenneth S Dyson 2 , Scott Nugent 2 , Felipe D Tancredi 1,3 , and Richard D Hoge 2

1 Centre de recherche de l'IUGM, Universit de Montral, Montreal, Quebec, Canada, 2 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, 3 Albert Einstein Jewish Hospital, Brazil

It is believed that the delivery and consumption of oxygen have an important role in the pathogenesis of conditions such as Alzheimers Disease (AD), rising the pertinence of developing technologies that provide such information. We demonstrate here the potential of the MRI method introduced in our team, dubbed QUO2, for characterizing age-related differences in cerebral physiology, more precisely in resting CBF, CVR, M, OEF and CMRO2. In the next step, we will use our protocol to evaluate the level of discrepancy between individuals diagnosed with AD and age-matched controls.

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