Assessment of Blood Brain Barrier Permeability in the Rat Brain with Ischemic Occlusion Using DSC-MRI
Ramesh Paudyal 1 , Silun Wang 1 , Yonggang Li 2 , Byron D Ford 2 , and Xiaodong Zhang 1
Yerkes Imaging Center, Yerkes Regional
Primate Research Center, Emory University, Atlanta, GA,
Neurosciences Institute, Morehouse School of Medicine,
Atlanta, GA, United States
The aim of this study was to assess the blood brain
barrier permeability in a rat stroke model induced by a
permanent middle cerebral artery occlusion (i.e., pMCAo)
using dynamic susceptibility contrast-MRI at 48 hr. Our
findings demonstrated that a leakage corrected blood
volume indicated the disruption of BBB in ischemic
injury at 48 hr.
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