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Abstract #2146

Assessment of Blood Brain Barrier Permeability in the Rat Brain with Ischemic Occlusion Using DSC-MRI

Ramesh Paudyal 1 , Silun Wang 1 , Yonggang Li 2 , Byron D Ford 2 , and Xiaodong Zhang 1

1 Yerkes Imaging Center, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA, United States, 2 Neurobiology, Neurosciences Institute, Morehouse School of Medicine, Atlanta, GA, United States

The aim of this study was to assess the blood brain barrier permeability in a rat stroke model induced by a permanent middle cerebral artery occlusion (i.e., pMCAo) using dynamic susceptibility contrast-MRI at 48 hr. Our findings demonstrated that a leakage corrected blood volume indicated the disruption of BBB in ischemic injury at 48 hr.

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