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Abstract #2147

Combine Diffusion Tensor Imaging and RGMa Immunohistochemical Analysis to Evaluate the Crossed Cerebellar Diaschisis in Rats after Middle Cerebral Artery Occlusion

Yong Zhang 1 , Jiangliang Cheng 1 , Yanan Lin 1 , Lu Yang 1 , Shanshan Zhao 1 , and Dandan Zheng 2

1 Dept. of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, 2 GE Healthcare, China, Beijing, China

The mechanism of cerebral infarction might be related to the theory of crossed cerebral-cerebellar diaschisis which pointed out that supratentorial focal brain damage could cause short functional changes in its fiber linked distant areas. In this study, we detected FA and the RGMa protein expression in remote regions of the infarct core in rats after MCAO at a continuous time point. The two values were analyzed to reveal the diffusion condition and pathological changes of the bilateral cerebellar hemispheres and hope to give more evidences about the relevant mechanism of crossed cerebellar diaschisis.

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