Abstract #2592
Diffusion tensor MRI of hearts with chronic infarct in multiple mechanical states
Maelene Lohezic 1 , Remi Peyronnet 2 , Craig A. Lygate 3 , Debra McAndrew 3 , Irvin Teh 1 , Peter Kohl 2,4 , and Jurgen E. Schneider 1
1
BMRU, Division of Cardiovascular Medicine,
Radcliffe Department of Medicine, University of Oxford,
Oxford, United Kingdom,
2
National
Heart and Lung Institute, Imperial College London,
London, United Kingdom,
3
Division
of Cardiovascular Medicine, Radcliffe Department of
Medicine, University of Oxford, Oxford, United Kingdom,
4
Department
of Computer Science, University of Oxford, Oxford,
United Kingdom
Myocardial microstructure is closely related to cardiac
function in health and disease, and can be assessed by
diffusion tensor imaging (DTI) throughout the cardiac
cycle in a non-destructive manner. We investigated
changes in DTI parameters in live isolated
chronically-infarcted rat hearts in three mechanical
states. Significant increase in the mean apparent
diffusion coefficient was observed in infarcted hearts
in the contractured state, while significant decrease in
fractional anisotropy was observed in infarcted hearts
in all three states. Furthermore, differences in primary
myocyte orientations were observed between healthy
hearts and the remote zone of infarcted hearts in the
relaxed state.
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