Abstract #2624
Bloch Equation Simulation with Slice Profile Correction (BLESSPC) T1 Estimation- Enabling accurate and precise myocardial T1 mapping at 3.0T using the FLASH-readout based MOLLI sequence
Jiaxin Shao 1 , Stanislas Rapacchi 1 , Kim-Lien Nguyen 1,2 , and Peng Hu 1,3
1
Department of Radiological Sciences, David
Geffen School of Medicine, University of California, Los
Angeles, CA, United States,
2
Department
of Medicine, Division of Cardiology, David Geffen School
of Medicine, University of Calif, Los Angeles, CA,
United States,
3
Biomedical
Physics Inter-Departmental Graduate Program, University
of California, Los Angeles, CA, United States
We developed the FLASH-MOLLI sequence using proposed
Bloch equation simulation with slice profile correction
(BLESSPC) for T1 estimation. The FLASH-MOLLI sequence
was evaluated against the bSSFP-MOLLI sequence using
phantom study, and in 10 healthy volunteers at 3.0T.
Phantom results show that the FLASH-MOLLI with BLESSPC
fitting reduced average T1 estimation error from
-58.550.6ms by bSSFP-MOLLI to -1.515.3ms for T1s from
440ms-1774ms and HRs from 40bpm-100bpm. The native
myocardial T1 values by FLASH-MOLLI were significantly
higher than that by bSSFP-MOLLI by 99.031.7ms
(1454.923.6ms vs. 1355.823.9ms, p<0.001) at heart
rates of 62.59.9 bpm, and FLASH-MOLLI is less sensitive
to off-resonance artifacts.
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