Abstract #2748
Validation of Intravascular Pressure Gradients Derived from Four-Dimensional Flow-Sensitive Magnetic Resonance: In Vitro Intraluminal Catheter Comparison Using an Elastic Phantom
Amir Awwad 1 , Daniel Rodrieguez 1 , Marcus Alley 2 , Shane MacSweeney 3 , Sebastian Kozerke 4 , and Dorothee P Auer 1
1
Sir Peter Mansfield Imaging Centre (SPMIC),
University of Nottingham, Nottingham, United Kingdom,
2
Radiological
Sciences Laboratories, Lucas Centre for Imaging,
Stanford University, Palo Alto, California, United
States,
3
Vascular
& Endovascular Surgery Dept., Nottingham University
Hospitals NHS Trust, Nottingham, United Kingdom,
4
Institute
of Biomedical Engineering, University and ETH Zurich,
Zurich, Switzerland
An in-vitro experimental study comparing derived
relative pressure gradients obtained using a 4D flow MRI
sequence (3 Tesla) with those measured using an
intraluminal fluid-filled pressure catheter readings.
Study utilises a custom-made whole body elastic vascular
phantom with continuous (stead-flow) pumping of a
slippery blood-analogue. Phantom-catheter setup is
assembled to be bubble-free, pre-calibrated (zero-level)
with dynamic 2nd-order (sinusoidal) response. Derivation
of relative pressure change is based on Navier-Stokes
Equations of velocity vector-fields (post-processing) in
a higher special/temporal resolutions. Experiment
results demonstrates the concordant potential in 4D flow
MRI to derive non-invasively intravascular relative
pressure gradients in continuous-flow dynamics.
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