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Abstract #2748

Validation of Intravascular Pressure Gradients Derived from Four-Dimensional Flow-Sensitive Magnetic Resonance: In Vitro Intraluminal Catheter Comparison Using an Elastic Phantom

Amir Awwad 1 , Daniel Rodrieguez 1 , Marcus Alley 2 , Shane MacSweeney 3 , Sebastian Kozerke 4 , and Dorothee P Auer 1

1 Sir Peter Mansfield Imaging Centre (SPMIC), University of Nottingham, Nottingham, United Kingdom, 2 Radiological Sciences Laboratories, Lucas Centre for Imaging, Stanford University, Palo Alto, California, United States, 3 Vascular & Endovascular Surgery Dept., Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 4 Institute of Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

An in-vitro experimental study comparing derived relative pressure gradients obtained using a 4D flow MRI sequence (3 Tesla) with those measured using an intraluminal fluid-filled pressure catheter readings. Study utilises a custom-made whole body elastic vascular phantom with continuous (stead-flow) pumping of a slippery blood-analogue. Phantom-catheter setup is assembled to be bubble-free, pre-calibrated (zero-level) with dynamic 2nd-order (sinusoidal) response. Derivation of relative pressure change is based on Navier-Stokes Equations of velocity vector-fields (post-processing) in a higher special/temporal resolutions. Experiment results demonstrates the concordant potential in 4D flow MRI to derive non-invasively intravascular relative pressure gradients in continuous-flow dynamics.

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