Evaluation of Cardiac Function in Chronic Kidney and Liver Disease
Charlotte E Buchanan 1,2 , Claire Grant 2 , Eleanor F Cox 1 , Nick M Selby 2,3 , Chris W McIntyre 2,4 , Maarten W Taal 2 , and Susan T Francis 1
SPMIC, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
of Medical Sciences and Graduate Entry Medicine, Royal
Derby Hospital, Nottingham, United Kingdom,
of Renal Medicine, Royal Derby Hospital, Derby, United
School of Medicine and Dentistry, University of Western
Ontario, London, Ontario, Canada
This study evaluates cardiac function in patients with
chronic kidney disease (CKD) and chronic liver disease
(CLD) in response to a handgrip challenge, which may be
more effective at discriminating normal from abnormal
cardiovascular function. Phase contrast imaging of the
aorta was performed during a handgrip challenge to
determine aortic strain, aortic velocity, cardiac
output, aorta area and stroke volume. Aortic strain
decreased significantly in CKD and HC on exercise.
Stroke volume was found to significantly increase on
exercise for patients with CLD.
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