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Abstract #2749

Evaluation of Cardiac Function in Chronic Kidney and Liver Disease

Charlotte E Buchanan 1,2 , Claire Grant 2 , Eleanor F Cox 1 , Nick M Selby 2,3 , Chris W McIntyre 2,4 , Maarten W Taal 2 , and Susan T Francis 1

1 SPMIC, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 Division of Medical Sciences and Graduate Entry Medicine, Royal Derby Hospital, Nottingham, United Kingdom, 3 Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom, 4 Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

This study evaluates cardiac function in patients with chronic kidney disease (CKD) and chronic liver disease (CLD) in response to a handgrip challenge, which may be more effective at discriminating normal from abnormal cardiovascular function. Phase contrast imaging of the aorta was performed during a handgrip challenge to determine aortic strain, aortic velocity, cardiac output, aorta area and stroke volume. Aortic strain decreased significantly in CKD and HC on exercise. Stroke volume was found to significantly increase on exercise for patients with CLD.

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