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Abstract #2880

Diffusion MRI of crossing fibers combining double pulsed field gradient (dPFG) eccentricity and q-ball imaging

Thomas Witzel 1 , Aapo Nummenmaa 1 , Qiuyun Fan 1 , Susie Yi Huang 1 , and Lawrence Leroy Wald 1,2

1 Department of Radiology, Harvard Medical School, A.A.Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2 Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

Fractional anisotropy (FA) is sensitive to intravoxel orientation dispersion, which may lead to reduced or very low FA values in regions of strong fiber crossings. Recent new measures of microscopic anisotropy have been proposed that are not influenced by the macroscopic orientation dispersion in the voxel, including the rotationally invariant eccentricity metric as well as the qMAS derived uFA. We use the rotationally invariant eccentricity approach to generate a metric which is insensitive to macroscopic orientation dispersion and combine the data with a conventional q-ball acquisition to demonstrate this metric's independence from the underlying crossing structure.

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