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Abstract #3033

Time-Dependent Influence of Cell Membrane Permeability on MR Diffusion

Hua Li 1 , Xiaoyu Jiang 1 , Jingping Xie 1 , J. Oliver Mclntyre 1 , John C. Gore 1 , and Junzhong Xu 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

The apparent diffusion coefficients (ADCs) within tumors were usually reported to increase after treatment, presumably because of the decreased cellularity. However, the cell membrane permeability was reported to increase following apoptotic cell death, which could also increase ADC. Due to short diffusion times, the oscillating gradient spin-echo (OGSE) methods are assumed to be relatively independent of changes of permeability. In the current study, we developed an experimental protocol to selectively alter cell membrane permeability, and then investigated its influence on diffusion measurements over a broad range of effective diffusion times (0.4 - 3000 ms).

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