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Abstract #3262

Quantification of Fluid Accumulation in IP Space of Mice using Whole-Body NMR

Lina Avancini Colucci 1 , Matthew Li 1 , and Michael J. Cima 2

1 Health Sciences and Technology (HST), MIT, Cambridge, Massachusetts, United States, 2 Materials Science and Engineering, MIT, Cambridge, Massachusetts, United States

This study investigated the use of whole-body NMR as a quantitative, sensitive, non-invasive technique of measuring fluid accumulation in the IP space of mice. Mice were given an IP injection of different saline volumes and their whole body T2 relaxation time was measured. The magnetization decay data was put through an inverse Laplace transform to generate a relaxogram. The saline injections resulted in an amplitude increase in the relaxograms long peak. The increase of the area under the peak was proportional to the volume of injected fluid. Ascitic fluid, similarly, has a long relaxation time compared to other body tissues.

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