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Abstract #3348

Accurate fitting of a Multi-Pool Proton Exchange System with a Priori Fitted Two-Pool MTC Information

Hye-Young Heo 1 , Yi Zhang 1 , Dong-Hoon Lee 1 , Xiaohua Hong 1 , and Jinyuan Zhou 1

1 Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States

APT imaging has been used to successfully detect malignant gliomas and other cancers. However, the mechanism of APT signal contrast in tumors is still unclear. In this study, we investigated the mixed effects of conventional MT, APT, and NOE using a fitting approach with a multiple-pool proton exchange model, and fitted the APT and NOE signals basing on the prior known, extrapolated semi-solid MTC information. The dependence of APT # and NOE # on the RF saturation power was also investigated.

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