Abstract #3442
Altered intrinsic anterior insular connectivity underlying social improvements in younger children with autism spectrum disorders
Wenjuan Wei 1 , Minghao Dong 2 , Yan Bai 3 , Wei Qin 2 , Ruwei Dai 1 , Meiyun Wang 3 , Dapeng Shi 3 , and Jie Tian 1,2
1
Key Laboratory of Molecular Imaging,
Institute of Automation, Chinese Academy of Science,
Beijing, Beijing, China,
2
School
of Life Sciences and Technology, Xidian University,
Xi'an, Shanxi, China,
3
Department
of Radiology, Henan Provincial People's Hospital,
zhengzhou, Henan, China
Autism spectrum disorders (ASD) are characterized as
neurodevelopmental disconnections between brain regions.
We investigated the altered intrinsic anterior insular
connectivity underlying social improvements using
resting-state functional MRI in younger children with
ASD. Our result of reduced intrinsic functional
connectivity in prefrontal cortex with improved social
ability in ASD children indicates that the functional
connectivity with PFC in ASD children may be
over-connected. Meanwhile, an increased connectivity
between right anterior insular cortex with
occipital-temporal region also suggests that the
occipital-temporal cortex may play a compensatory role
in ASD.
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