Characterization of Thermochemical Ablation Injections using 23 Na MRI
Florian Maier 1 , Erik N. K. Cressman 2 , Moritz C. Berger 1 , David Fuentes 3 , R. Jason Stafford 3 , Christopher J. MacLellan 3 , Reiner Umathum 1 , and Armin M. Nagel 1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany,
Radiology, The University of Texas MD Anderson Cancer
Center, Houston, TX, United States,
Physics, The University of Texas MD Anderson Cancer
Center, Houston, TX, United States
Thermochemical ablation (TCA) provides a novel concept
in minimally invasive ablative procedures in which two
reactive solutions, such as acetic acid and sodium
hydroxide, release heat as they react prior to entering
the tissue as sodium acetate (NaOAc) solution. Besides
thermal damage, additional damage is caused by the
hyperosmolar environment after injection. In this work,
MRI is used to image NaOAc distributions to provide more
detailed insight for effective delivery.
MRI of TCA injections will facilitate a platform for the
design and optimization of applicators as well as
development and validation of computational models, and
progress towards clinical translation.
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