Multinuclear ( 19 F + 1 H) MRI at 3T using an internal probe
Shashank Sathyanarayana Hegde 1 , Li Pan 2 , Guan Wang 1,3 , Martin Radvany 1 , Yingli Fu 1 , and Dara L Kraitchman 1
Radiology, Johns Hopkins University,
Baltimore, Maryland, United States,
Healthcare, Baltimore, Maryland, United States,
and Computer Engineering, Johns Hopkins University,
Maryland, United States
We developed and characterized an internal probe at 3T
designed for interchangeable
use. The internal probe demonstrated increased
signal-to-noise ratio with respect to a conventional
surface coil for structures deeper than 2 cm from the
imaging of ~7.5mL of a 10-fold dilution (e.g., 5 mg/ml)
of fluorouracil (5-FU) was possible in 2 minutes.
Multinuclear MRI of perfluorooctyl bromide (PFOB)
microcapsules was performed in tissue samples ex vivo
and a rabbit thigh in vivo. High-resolution (0.2 mm
and 0.8 mm
in-plane) MRI of PFOB capsules was possible and was
concordant with cone beam computed tomography (CT)
imaging of the radiopaque microcapsules.
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