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Abstract #4323

Diffusion kurtosis imaging reveals widespread white matter abnormalities in Alzheimer' s disease

Weiwei Wang 1 , Rui Hu 1 , Ziheng Zhang 2 , Qingwei Song 1 , Ailian Liu 1 , and Yanwei Miao 1

1 Radiology Department, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China, 2 GE Healthcare China, Beijing, China

Alzheimer's disease (AD) is the most common CNS degenerative disease in aged people and causes senile dementia1. Diffusion kurtosis imaging (DKI) is a method that can obtain the non-Gaussian diffusion of water. This work was to evaluate the application of DKI on white matter microstructure damage examination in AD, and it was found DKI can quantitatively evaluate the white matter changes in AD patients and the Dr values in the temporal WM can be as the best individual biomarkers of differentiation AD to controls. In addition, the changes of DKI parameters indicated the axonal loss and myelin damage of AD

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