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Abstract #4324

Comparisons of QSM Data obtained from a single echo and multiple echoes in patients with cognitive normal, mild cognitive impairment, and Alzheimer s Disease

Hyug-Gi Kim 1 , Dan-Bi Kim 2 , Jang-Hoon Oh 1 , Hak Young Rhee 3 , Chang-Woo Ryu 2 , Soon Chan Park 2 , Dal-Mo Yang 2 , Yi Wang 1,4 , Tian Liu 4 , and Geon-Ho Jahng 2

1 Biomedical Engineering, Kyung Hee University, YoungIn, Gyeonggi-do, Korea, 2 Radiology, Kyung Hee University Hospital-Gangdong, Seoul, Korea, 3 Neurology, Kyung Hee University Hospital-Gangdong, Seoul, Korea, 4 Biomedical Engineering and Radiology, Cornell University, New York, New York, United States

To estimate the quantitative susceptibility effect on a number of echoes of gradient-echo sequences, two sequences were run in subjects with cognitive normal (CN), mild cognitive impairment (MCI) and Alzheimers diseases (AD). Quantitative susceptibility mapping (QSM) was reconstructed with the single-echo (seQSM) and with multiple-echo (meQSM) data. QSM maps were compared among three groups. We found higher sensitivity of meQSM data than seQSM data. The meQSM technique has been proposed to accurately estimate the amounts of irons compared with seQSM technique. In addition, QSM was useful to investigate susceptibility effects in AD brain with the voxel-based analyses.

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