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Abstract #4466

Hemorrhage alters T2 BOLD response in remote myocardium following acute myocardial infarction in a porcine model

Nilesh R Ghugre 1,2 , Xiuling Qi 1 , Jennifer Barry 1 , Bradley H Strauss 3 , and Graham A Wright 1,2

1 Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 2 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3 Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Myocardial hemorrhage is a frequent complication in acute myocardial infarction; however its impact on the remote tissue is currently unknown. The aim of our study was to investigate whether hemorrhage contributes to a remote myocardial response using a novel porcine model of myocardial hemorrhage. To this end, a blood-oxygen-level-dependent (BOLD) approach with T2 contrast was employed to evaluate vasodilator function using a stress agent. We noted an elevated remote T2 in the rest state that was associated with a suppressed stress response under hemorrhagic conditions. Our study demonstrates that hemorrhage not only promotes cellular and microvascular damage and inflammation but may also further be responsible for remote myocardial remodeling post-infarction.

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