Abstract #4466
Hemorrhage alters T2 BOLD response in remote myocardium following acute myocardial infarction in a porcine model
Nilesh R Ghugre 1,2 , Xiuling Qi 1 , Jennifer Barry 1 , Bradley H Strauss 3 , and Graham A Wright 1,2
1
Physical Sciences Platform, Sunnybrook
Research Institute, Toronto, ON, Canada,
2
Department
of Medical Biophysics, University of Toronto, Toronto,
ON, Canada,
3
Schulich
Heart Program, Sunnybrook Health Sciences Centre,
Toronto, ON, Canada
Myocardial hemorrhage is a frequent complication in
acute myocardial infarction; however its impact on the
remote tissue is currently unknown. The aim of our study
was to investigate whether hemorrhage contributes to a
remote myocardial response using a novel porcine model
of myocardial hemorrhage. To this end, a
blood-oxygen-level-dependent (BOLD) approach with T2
contrast was employed to evaluate vasodilator function
using a stress agent. We noted an elevated remote T2 in
the rest state that was associated with a suppressed
stress response under hemorrhagic conditions. Our study
demonstrates that hemorrhage not only promotes cellular
and microvascular damage and inflammation but may also
further be responsible for remote myocardial remodeling
post-infarction.
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