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Abstract #4467

Intralipid Reduces Post-MI Ventricular Remodeling and Heart Failure after Ischemic Injury

Yijen Lin Wu 1,2 , Fang-Cheng Yeh 3 , and Chien Ho 4

1 Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Rangos Research Center Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 3 Psychology, Carnegie Mellon University, Pittsburgh, PA, United States, 4 Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States

Coronary heart disease is the leading cause of death in US. Timely re-circulation has greatly decreased 30-day in-hospital death, and increased survival rate during the acute phase of myocardium infarction (MI). However, even with successful blood-flow restoration, ischemia reperfusion injury (IRI) can result in greater tissue damage and adverse remodeling. The rate of developing post-MI heart failure increases as the acute mortality decreases. Long-term post-MI ventricular remodeling and the consequent potential heart failure remains a challenge. We report here that Intralipid can preserve heart function after IRI can reduce long-term post-MI ventricular remodeling.

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