Early detection of doxorubicin induced diffuse myocardial fibrosis by contrast enhanced magnetic resonance imaging in rabbit modell: compared with histology and electron microscopy.
Byoung Wook Choi 1 , Yoo Jin Hong 1 , Chul Hwan Park 1 , and Panki Kim 1
Radiology, Yonsei University, Seoul, Korea
Cardiotoxicity of doxorubicin in patients with cancer
causes irreversible myocardial damage leading to worse
prognosis. To detect early stage of cardiotoxicity, T1
mapping and extracellular volume fraction was tested to
determine the feasibility for detection of diffuse
myocardial fibrosis in an early stage of cardiotoxicity.
There was a good correlation between myocardial ECV
measurement and the degree of fibrosis on histology.
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