Abstract #0011

Investigation of the influence of the extracellular matrix on water diffusion in brain and cartilage

Jakob Georgi¹, Riccardo Metere¹, Markus Morawski², Carsten Jäger², and Harald E. Möller¹

¹Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Paul-Flechsig-Institute for Brain Research, Leipzig, Germany

Water diffusivity in biological tissues can be related to the underlying microstructure that modulates the restricted or hindered diffusion, and can be studied with NMR experiments. The extracellular matrix, whose composition depends on the tissue type, may have an influence on diffusion. In this work we study the influence of the extracellular matrix on diffusion, by measuring brain and cartilage samples before and after the enzymatic removal of the extracellular matrix components. The activation energy for the self-diffusion of water seems to be not significantly affected by the treatment for brain tissues.

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