Abstract #0012

Measurement of the Effect of Tissue Fixation on Tumour Microstructure using VERDICT Diffusion-MRI

Ben Jordan¹, Tom Roberts¹, Angela D'Esposito¹, John Connell¹, Andrada Ianus², Eleftheria Panagiotaki², Daniel Alexander², Mark Lythgoe¹, and Simon Walker-Samuel¹

¹Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²Centre for Medical Image Computing, University College London, London, United Kingdom

It has previously been shown that compartmental models of tissue diffusion such as VERDICT can enable access to useful measures of in-vivo tumour microstructure such as cell radius. However, comparing the in-vivo values with those measured from histology showed that a discrepancy exists between the two; histological values were consistently smaller. In this study, we assess the ability of VERDICT MRI to detect this change in cell radius by acquiring data (9.4T MRI) both in-vivo and post-fixation. A significant decrease in cell radius was detected post-fixation, which was supported by a decrease in the intra-cellular volume fraction.

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