Meeting Banner
Abstract #0072

Imaging Cartilage-Bone Interactions in Osteoarthritis using Simultaneous 18F-NaF PET-MR imaging– the “Bone-Cartilage Connectome”

Dragana Savic1,2, Valentina Pedoia1, Youngho Seo1, Matthew Bucknor1, Benjamin Franc1, and Sharmila Majumdar1

1University of California San Francisco, San Francisco, CA, United States, 2University of Oxford, Oxford, United Kingdom

This first in human study evaluated cartilage biochemistry and bone function in sixteen knee osteoarthritis patients using simultaneous Time-Of-Flight (TOF) PET/MR imaging. Bone turnover and blood flow was studied using 18F Sodium Fluoride (NaF) and quantitative voxel by voxel MR derived T relaxation times characterizing the biochemical cartilage degeneration. Increased degeneration of cartilage, was associated with increased turnover in the adjoining bone as well as in the non-adjoining compartments. These observations highlight the complex biomechanical and biochemical interactions in the whole knee joint, alluding to a “bone-cartilage connectome”, that potentially changes during the natural history of the disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here