Abstract #0073

Dynamic analysis of [18F]-sodium fluoride uptake in knee osteoarthritis with PET-MRI

Audrey P Fan¹, Feliks Kogan¹, Aleema Patel¹, Edwin HG Oei², Andrew Quon¹, and Garry E Gold¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Erasmus MC: University Medical Center Rotterdam, Rotterdam, Netherlands

This study investigates dynamic uptake of [18F]-fluoride in bone marrow lesions (BMLs) and osteophytes observed on MRI of patients with knee osteoarthritis. Through kinetic modeling, we characterized rate constants of bone metabolism in bone pathology relative to healthy bone. BMLs and higher-grade osteophytes showed higher total bone metabolism K_i (P < 0.01) and higher bone mineralization rate k₃ (P < 0.01) relative to grade 1 osteophytes and normal bone. While a similar trend was observed for blood flow, the differences from normal tissue were subtler suggests that rate of mineralization k₃ and not blood flow is a key driver of [¹⁸F]-fluoride accumulation in OA lesions. These new physiological parameters may help differentiate between different grades of OA lesions or identify which lesions are active parts of the disease process.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.