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Abstract #0073

Dynamic analysis of [18F]-sodium fluoride uptake in knee osteoarthritis with PET-MRI

Audrey P Fan1, Feliks Kogan1, Aleema Patel1, Edwin HG Oei2, Andrew Quon1, and Garry E Gold1

1Radiology, Stanford University, Stanford, CA, United States, 2Erasmus MC: University Medical Center Rotterdam, Rotterdam, Netherlands

This study investigates dynamic uptake of [18F]-fluoride in bone marrow lesions (BMLs) and osteophytes observed on MRI of patients with knee osteoarthritis. Through kinetic modeling, we characterized rate constants of bone metabolism in bone pathology relative to healthy bone. BMLs and higher-grade osteophytes showed higher total bone metabolism Ki (P < 0.01) and higher bone mineralization rate k3 (P < 0.01) relative to grade 1 osteophytes and normal bone. While a similar trend was observed for blood flow, the differences from normal tissue were subtler suggests that rate of mineralization k3 and not blood flow is a key driver of [18F]-fluoride accumulation in OA lesions. These new physiological parameters may help differentiate between different grades of OA lesions or identify which lesions are active parts of the disease process.

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