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Abstract #0501

A robust T1ρ-mapping method for in-vivo glucose detection at 7T whole-body scanners

Patrick Schuenke1, Moritz Zaiss1, Christina Koehler2, Alexander Radbruch2,3, Mark Edward Ladd1, and Peter Bachert1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany, 3Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Recently it was demonstrated that on–resonant chemical–exchange–sensitive spin–lock (CESL) allows to observe the uptake of administered D–glucose in vivo and thus could be used for glucose metabolism studies. However, conventional spin–lock produces artifacts owing to B1–field inhomogeneities, which are a common problem especially at high-field whole-body MR scanners. Therefore we developed an adiabatic water–T mapping sequence which outperforms conventional spin-lock sequences with respect to its insensitivity to B1–inhomogeneities; its sensitivity to glucose in the millimolar range as well as its applicability to in vivo studies is proven.

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