Abstract #0501

A robust T1ρ-mapping method for in-vivo glucose detection at 7T whole-body scanners

Patrick Schuenke¹, Moritz Zaiss¹, Christina Koehler², Alexander Radbruch^2,3, Mark Edward Ladd¹, and Peter Bachert¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany, ³Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Recently it was demonstrated that on–resonant chemical–exchange–sensitive spin–lock (CESL) allows to observe the uptake of administered D–glucose in vivo and thus could be used for glucose metabolism studies. However, conventional spin–lock produces artifacts owing to B₁–field inhomogeneities, which are a common problem especially at high-field whole-body MR scanners. Therefore we developed an adiabatic water–T_1ρ mapping sequence which outperforms conventional spin-lock sequences with respect to its insensitivity to B₁–inhomogeneities; its sensitivity to glucose in the millimolar range as well as its applicability to in vivo studies is proven.

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