Abstract #0502

Imaging Subcortical White Matter by High Resolution 7 T MRI in vivo: Towards Potential U-Fiber Density Mapping in Humans

Evgeniya Kirilina^1,2, Juliane Dinse¹, Pierre-Louise Bazin¹, Carsten Stueber^3,4, Stefan Geyer¹, Robert Trample¹, Andreas Deistung⁵, Juergen R Reichenbach⁵, and Nikolaus Weiskopf^1,6

¹Neurophysics, Max Plank Institute for Human Cognitive and Brain Science, Leipzig, Germany, ²Neurocomputation and Neuroimaging Unit, Department of Educational Science and Psychology, Free University Berlin, Berlin, Germany, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, United States, ⁵Medical Physics Group, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ⁶Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom

Subcortical white matter (SWM) incorporates U-fibers, the intra-hemispheric connections between adjacent gyri. Despite their importance for cortical connectivity little is known about the U-fiber distribution in humans due to the lack of appropriate imaging methods. Herein we investigate SWM using high-resolution in-vivo MRI at 7T. A clear-cut discrimination of SWM from the adjacent brain regions was obtained based on higher qR₂*, qR₂ and susceptibility in-vivo. These new findings may pave the way for future in-vivo segmentation strategies for this crucial brain region as well as potential U-fiber density mapping in humans.

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