Meeting Banner
Abstract #0502

Imaging Subcortical White Matter by High Resolution 7 T MRI in vivo: Towards Potential U-Fiber Density Mapping in Humans

Evgeniya Kirilina1,2, Juliane Dinse1, Pierre-Louise Bazin1, Carsten Stueber3,4, Stefan Geyer1, Robert Trample1, Andreas Deistung5, Juergen R Reichenbach5, and Nikolaus Weiskopf1,6

1Neurophysics, Max Plank Institute for Human Cognitive and Brain Science, Leipzig, Germany, 2Neurocomputation and Neuroimaging Unit, Department of Educational Science and Psychology, Free University Berlin, Berlin, Germany, 3Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 4Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, United States, 5Medical Physics Group, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 6Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom

Subcortical white matter (SWM) incorporates U-fibers, the intra-hemispheric connections between adjacent gyri. Despite their importance for cortical connectivity little is known about the U-fiber distribution in humans due to the lack of appropriate imaging methods. Herein we investigate SWM using high-resolution in-vivo MRI at 7T. A clear-cut discrimination of SWM from the adjacent brain regions was obtained based on higher qR2*, qR2 and susceptibility in-vivo. These new findings may pave the way for future in-vivo segmentation strategies for this crucial brain region as well as potential U-fiber density mapping in humans.

This abstract and the presentation materials are available to members only; a login is required.

Join Here