Abstract #0503

Mapping orientation dependent and independent components of R2star in the human white matter - an in vivo study

Diana Khabipova^1,2, Rita Gil², Marcel Zwiers², and José Pedro Marques²

¹CIBM-AIT, EPFL, Lausanne, Switzerland, ²Centre for Cognitive Neuroimaging, Donders Institute, Nijmegen, Netherlands

Anisotropic microstructure of the white matter causes the apparent transverse relaxivity, $$$R_2^*$$$, to depend on the orientation of white matter fibres in respect to the applied magnetic field. Using the fibre orientation prior knowledge from DTI orientation dependent $$$R_{2,ANISO}^*$$$ and independent $$$R_{2,ISO}^*$$$ components of $$$R_2^*$$$ were calculated. For all studied WM fibres a consistency for the (an)isotropic components between both hemispheres was present. The isotropic component showed higher variability compared to the anisotropic component.

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