Jingwei Zhang1,2, Dong Zhou2, Sarah Eskreis-Winkler2, Thanh Nguyen2, Pascal Spincemaille2, Ajay Gupta2, and Yi Wang1,2
1Biomedical Engineering, Cornell University, New York, NY, United States, 2Radiology, Weill Cornell Medical College, New York, NY, United States
We propose a cerebral
metabolic rate of oxygen consumption (CMRO2) mapping method without blood flow
challenge using quantitative susceptibility mapping, cerebral blood flow and a
regularization of minimal local variance (MLV) within the same type of tissue.
Getting rid of blood flow challenge would vastly increase the clinical
utility of MRI CMRO2. The MNV CMRO2 maps were very
similar to CMRO2 maps using caffeine as challenge, with no
significant bias in value.