Meeting Banner
Abstract #0665

A new paradigm to assess brain cell microstructure by diffusion-weighted magnetic resonance spectroscopy: proof of concept and initial results in the macaque brain

Marco Palombo1,2, Clémence Ligneul1,2, Chloé Najac1,2, Juliette Le Douce1,2, Julien Flament1,2, Carole Escartin1,2, Philippe Hantraye1,2, Emmanuel Brouillet1,2, Gilles Bonvento1,2, and Julien Valette1,2

1CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, 2CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France

We introduce a novel paradigm for non-invasive brain microstructure quantification, where original diffusion modeling is merged with cutting-edge diffusion-weighted spectroscopy (DW-MRS) experiments to capture features of cellular morphology that have remained largely ignored by DW-MRI. A compact description of long-range cellular morphology is used to randomly generate large collections of synthetic cells where particles diffusion is simulated. After investigating model robustness, we apply it on metabolite ADC measured in vivo in the monkey brain up to td=2 seconds. The new paradigm introduced here opens new possibilities to non-invasively extract quantitative information about cell size, complexity and heterogeneity in the brain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here