Hyperpolarized 13C-Urea MRI for the assessment of the urea gradient in the porcine kidney
Esben Søvsø Szocska Hansen1,2, Neil James Stewart3, Jim Michael Wild3, Hans Stødkilde-Jørgensen1, and Christoffer Laustsen1
1MR Research Centre, Aarhus University, Aarhus N, Denmark, 2Danish Diabetes Academy, Odense, Denmark, 3Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom
Renal anatomical and pathophysiological alterations
are directly associated with the fluid and electrolyte balance in the kidney,
which is regulated by the extracellular corticomedullary osmolality gradient. We
introduce a novel magnetic resonance imaging (MRI) approach to monitor the
corticomedullary osmolality gradient changes using hyperpolarized 13C-urea in a healthy porcine model. A corticomedullary urea gradient was observed
with an intra-medullary accumulation after 75s of hyperpolarized 13C-urea
injection, while earlier time points were dominated by cortical perfusion. Furosemide
treatment resulted in an increased urea accumulation in the cortical space. This
work demonstrates intra-renal functional assessment with hyperpolarized 13C-urea
MRI in multi-papillary kidneys.
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