Abstract #0666

Hyperpolarized 13C-Urea MRI for the assessment of the urea gradient in the porcine kidney

Esben Søvsø Szocska Hansen^1,2, Neil James Stewart³, Jim Michael Wild³, Hans Stødkilde-Jørgensen¹, and Christoffer Laustsen¹

¹MR Research Centre, Aarhus University, Aarhus N, Denmark, ²Danish Diabetes Academy, Odense, Denmark, ³Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Renal anatomical and pathophysiological alterations are directly associated with the fluid and electrolyte balance in the kidney, which is regulated by the extracellular corticomedullary osmolality gradient. We introduce a novel magnetic resonance imaging (MRI) approach to monitor the corticomedullary osmolality gradient changes using hyperpolarized ¹³C-urea in a healthy porcine model. A corticomedullary urea gradient was observed with an intra-medullary accumulation after 75s of hyperpolarized ¹³C-urea injection, while earlier time points were dominated by cortical perfusion. Furosemide treatment resulted in an increased urea accumulation in the cortical space. This work demonstrates intra-renal functional assessment with hyperpolarized ¹³C-urea MRI in multi-papillary kidneys.

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