Abstract #0667

In vivo measurement of Renal Redox Capacity in a Model of Chronic Kidney Disease using by hyperpolarized 13C dehydroascorbate (DHA) MRS

Celine A.J. Baligand¹, David H. Lovett², Lalita Uttarwar², Jeremy Gordon¹, John Kurhanewicz¹, David M. Wilson¹, and Zhen Jane Wang¹

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Medicine, San Francisco Department of Veterans Affairs Medical Center/University of California San Francisco, San Francisco, CA, United States

Limited biomarkers are available for early diagnosis and monitoring of chronic kidney disease (CKD). Renal oxidative stress is a key initiator of CKD. Therefore, in vivo assessment of kidney redox capacity may provide a clinically relevant and early marker of kidney injury. The N-terminal truncated matrix metalo-protease isoform (NTT-MMP-2) transgenic mouse is a model mimicking human progressive kidney disease that is triggered by oxidative stress. Using this model, we show that hyperpolarized ¹³C-dehydroascobic acid MRS imaging can detect in vivo the altered redox capacity preceding any functional and histological changes, thus potentially providing an early marker of susceptibility to CKD.

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