Meeting Banner
Abstract #0667

In vivo measurement of Renal Redox Capacity in a Model of Chronic Kidney Disease using by hyperpolarized 13C dehydroascorbate (DHA) MRS

Celine A.J. Baligand1, David H. Lovett2, Lalita Uttarwar2, Jeremy Gordon1, John Kurhanewicz1, David M. Wilson1, and Zhen Jane Wang1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Medicine, San Francisco Department of Veterans Affairs Medical Center/University of California San Francisco, San Francisco, CA, United States

Limited biomarkers are available for early diagnosis and monitoring of chronic kidney disease (CKD). Renal oxidative stress is a key initiator of CKD. Therefore, in vivo assessment of kidney redox capacity may provide a clinically relevant and early marker of kidney injury. The N-terminal truncated matrix metalo-protease isoform (NTT-MMP-2) transgenic mouse is a model mimicking human progressive kidney disease that is triggered by oxidative stress. Using this model, we show that hyperpolarized 13C-dehydroascobic acid MRS imaging can detect in vivo the altered redox capacity preceding any functional and histological changes, thus potentially providing an early marker of susceptibility to CKD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here