Celine A.J. Baligand1, David H. Lovett2, Lalita Uttarwar2, Jeremy Gordon1, John Kurhanewicz1, David M. Wilson1, and Zhen Jane Wang1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Medicine, San Francisco Department of Veterans Affairs Medical Center/University of California San Francisco, San Francisco, CA, United States
Limited biomarkers are
available for early diagnosis and monitoring of chronic kidney disease (CKD).
Renal oxidative stress is a key initiator of CKD. Therefore, in vivo assessment
of kidney redox capacity may provide a clinically relevant and early marker of
kidney injury. The N-terminal truncated matrix metalo-protease isoform
(NTT-MMP-2) transgenic mouse is a model mimicking human progressive kidney
disease that is triggered by oxidative stress.
Using this model, we show that hyperpolarized 13C-dehydroascobic acid
MRS imaging can detect in vivo the altered redox capacity preceding any functional
and histological changes, thus potentially providing an early marker of
susceptibility to CKD.