Abstract #0668

Maternal-fetal exchanges characterized by dynamic hyperpolarized 13C imaging on pregnant rats

Anne Fages¹, Tangi Roussel¹, Marina Lysenko², Ron Hadas², Michal Neeman², and Lucio Frydman¹

¹Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ²Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Dynamic nuclear polarization (DNP) enhanced ¹³C MRI of hyperpolarized (HP) urea and bicarbonate has been applied to monitor metabolic fluxes from the maternal blood pool to the fetuses, in pregnant rats at late gestation stage. This use of HP metabolites offers a non-invasive way to observe details of active and passive maternal-fetal exchanges.

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