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Abstract #0668

Maternal-fetal exchanges characterized by dynamic hyperpolarized 13C imaging on pregnant rats

Anne Fages1, Tangi Roussel1, Marina Lysenko2, Ron Hadas2, Michal Neeman2, and Lucio Frydman1

1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Dynamic nuclear polarization (DNP) enhanced 13C MRI of hyperpolarized (HP) urea and bicarbonate has been applied to monitor metabolic fluxes from the maternal blood pool to the fetuses, in pregnant rats at late gestation stage. This use of HP metabolites offers a non-invasive way to observe details of active and passive maternal-fetal exchanges.

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