Abstract #0669

Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate

Stephen J DeVience¹, Xin Lu¹, Julie Proctor², Parisa Rangghran², Rao Gullapalli¹, Gary M Fiskum^2,3,4, and Dirk Mayer¹

¹Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, ²Anesthesiology, University of Maryland, Baltimore, MD, United States, ³Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD, United States, ⁴Pharmacology, University of Maryland, Baltimore, MD, United States

We investigated the use of hyperpolarized ¹³C-pyruvate imaging as a direct, non-invasive method for identifying traumatic brain injury and studying its effects on energy metabolism. Rats were injured with a controlled cortical impact device and then injected with [1-¹³C]pyruvate. Spectrally-resolved imaging was performed on the brain to quantify the resulting pyruvate, lactate, and bicarbonate signals. The ratio of lactate to bicarbonate signal was found to be sensitive to traumatic brain injury, with the relative increase in lactate signal and decrease in bicarbonate (formed from CO₂) at the injury site suggesting a transition to anaerobic respiration.

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