Abstract #0670

In Vivo pH and Metabolite MR Imaging Using Hyperpolarized 13C-Pyruvate

Nicholas Drachman¹, Stephen J. Kadlecek¹, Mehrdad Pourfathi^1,2, Yi Xin¹, Harrilla Profka¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, United States

In this study, we investigate the possibility of simultaneously imaging pH and lactate to pyruvate ratio in vivo in the lungs. We produce hyperpolarized ¹³C-bicarbonate by rapidly decarboxylating hyperpolarized [1-¹³C]pyruvate with hydrogen peroxide. By tuning the reaction rate by altering the pH, we produce roughly equal amounts of pyruvate and bicarbonate, which allows us to image both metabolic processes simultaneously.

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