Abstract #0671

Tumor Progression, Regression, and Recurrence Monitoring using Hyperpolarized [1-13C]Pyruvate Metabolic Imaging in a Murine Breast Cancer Model

Peter jinwoo Shin¹, Zihan Zhu¹, Roman Camarda², Robert Bok¹, Alicia Zhou², Andrei Goga², and Daniel B Vigneron¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Biomedical Science Program, University of California, San Francisco, San Francisco, CA, United States

We used hyperpolarized [1-¹³C]pyruvate imaging to monitor tumor progression and regression in a murine breast cancer model that conditionally expresses the human c-MYC transgene in a doxycycline switchable manner. Previously, it was shown that this model could develop a secondary tumor even after the primary tumor regresses nearly fully following c-MYC deinduction. Hence, the purpose of this project was to monitor altered glycolytic metabolism by hyperpolarized metabolic MRI in this multi-stage mammary tumorigenesis animal model.

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