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Abstract #0976

Diffusion-weighted MR Imaging (DW-MRI) in advanced epithelial ovarian and primary peritoneal cancer: anatomic site-specific changes following neoadjuvant chemotherapy for detecting residual viable tumor

Jennifer C Wakefield1,2, Jessica M Winfield1,2, Gordon Stamp3, Alison MacDonald2, Charlotte Hodgkin4, Ayoma Attygalle2, Desmond Barton2, Robin Crawford4, Susan Freeman4, and Nandita M deSouza1,2

1Division of Radiotherapy and Imaging, Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, 2The Royal Marsden Hospital, Sutton, United Kingdom, 3Department of Medicine, Centre for Pathology, Imperial College London, London, United Kingdom, 4Departments of Gynaecological Oncology and Radiology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

An understanding of the apparent diffusion coefficient (ADC) changes following neoadjuvant chemotherapy at different metastatic sites in advanced ovarian and primary peritoneal cancer is essential to establish the utility of ADC as a biomarker in site-specific response assessment in this disease. In this study, we found that there was variability in the detection accuracy of DW-MRI between different disease sites and the ADC shows utility as an adjunct to morphological imaging for the detection of viable tumor. Further studies with larger numbers of lesions are needed to interrogate differences between microscopic and non-viable and residual macroscopic tumor fully.

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