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Abstract #0977

Diagnostic Performance of Endovaginal Zoom EPI Images for Detecting Cervix Cancer after Distortion Correction using Gradient Reversal

Nandita deSouza1, Matthew Orton1, Kate Downey1, Veronica Morgan1, David Collins1, Sharon Giles1, and Geoffrey Payne1

1CRUK/EPSRC Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

Diffusion-weighted MRI (DW-MRI) suffers from distortion induced by susceptibility variation and eddy-currents. To correct this for endovaginal imaging of the uterine cervix, we implemented the forward and reversed gradient technique proposed by Chang and Fitzpatrick in the phase-encode direction and assessed clinical utility of the technique. This required acquisition of two images of the cervix under the same conditions. Correction of distortions significantly improved diagnostic performance for an experienced observer when images were viewed with the T2-W images. Correction allowed definitive diagnosis in a third of cases with tumour volumes of <0.2cm3 classified as equivocal on uncorrected images.

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