Lucas Lindeboom1,2,3, Robin A. de Graaf4, Christine I. Nabuurs1,2,3, Matthijs K.C. Hesselink2, Joachim E. Wildberger1, Patrick Schrauwen2,3, and Vera B. Schrauwen-Hinderling1,2,3
1Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 2Human Biology and Human Movement Sciences, Maastricht University Medical Center, Maastricht, Netherlands, 3Top Institute Food and Nutrition, Wageningen, Netherlands, 4Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT, United States
We here show that postprandial 13C
fatty acid tracking is feasible in the human liver using ge-HSQC. Experiments
in two human volunteers revealed that intake of 5 or 7 grams of 13C-labeled
fatty acids resulted in two- or threefold increase in hepatic 13C-enrichment
after 3 hours. It is estimated that 3% of the oral load is stored in the liver
at this time point. The ge-HSQC sequence can be used to reveal the contribution
of dietary fat to the development of hepatic steatosis.
