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Abstract #1053

Non-invasive postprandial fatty acid tracking with 1H-[13C] Magnetic Resonance Spectroscopy in the human liver

Lucas Lindeboom1,2,3, Robin A. de Graaf4, Christine I. Nabuurs1,2,3, Matthijs K.C. Hesselink2, Joachim E. Wildberger1, Patrick Schrauwen2,3, and Vera B. Schrauwen-Hinderling1,2,3

1Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 2Human Biology and Human Movement Sciences, Maastricht University Medical Center, Maastricht, Netherlands, 3Top Institute Food and Nutrition, Wageningen, Netherlands, 4Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT, United States

We here show that postprandial 13C fatty acid tracking is feasible in the human liver using ge-HSQC. Experiments in two human volunteers revealed that intake of 5 or 7 grams of 13C-labeled fatty acids resulted in two- or threefold increase in hepatic 13C-enrichment after 3 hours. It is estimated that 3% of the oral load is stored in the liver at this time point. The ge-HSQC sequence can be used to reveal the contribution of dietary fat to the development of hepatic steatosis.

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