Abstract #1053

Non-invasive postprandial fatty acid tracking with 1H-[13C] Magnetic Resonance Spectroscopy in the human liver

Lucas Lindeboom^1,2,3, Robin A. de Graaf⁴, Christine I. Nabuurs^1,2,3, Matthijs K.C. Hesselink², Joachim E. Wildberger¹, Patrick Schrauwen^2,3, and Vera B. Schrauwen-Hinderling^1,2,3

¹Radiology, Maastricht University Medical Center, Maastricht, Netherlands, ²Human Biology and Human Movement Sciences, Maastricht University Medical Center, Maastricht, Netherlands, ³Top Institute Food and Nutrition, Wageningen, Netherlands, ⁴Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT, United States

We here show that postprandial ¹³C fatty acid tracking is feasible in the human liver using ge-HSQC. Experiments in two human volunteers revealed that intake of 5 or 7 grams of ¹³C-labeled fatty acids resulted in two- or threefold increase in hepatic ¹³C-enrichment after 3 hours. It is estimated that 3% of the oral load is stored in the liver at this time point. The ge-HSQC sequence can be used to reveal the contribution of dietary fat to the development of hepatic steatosis.

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