Abstract #1054

Detection of human brown adipose tissue by MRI with hyperpolarized Xe-129 gas and validation by FDG-PET/MRI

Rosa Tamara Branca^1,2, Le Zhang^3,4, Alex Burant^1,4, Laurence Katz⁵, and Andrew McCallister^1,4

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, Chapel Hill, NC, United States, ³Material Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Despite histological evidence that all humans have brown adipose tissue, the detection of this tissue in overweighs and obese subjects has proven to be a challenge. A recent study showed that MRI by hyperpolarized xenon gas (HP129Xe) enables the detection of this tissue in both lean and obese animal phenotype, with enhanced sensitivity in the latter with respect to the gold standard, FDG-PET. Here we demonstrate that HP129Xe gas MRI can also be used to detect human BAT with better sensitivity than FDG-PET.

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