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Abstract #1170

3D FLASH Optimization with Improved Contrast Efficiency and Image Inhomogeneity Correction

Jinghua Wang1, Lili He2, and Zhong-Lin Lu1

1The Ohio State Univeristy, Columbus, OH, United States, 2Center for Perinatal Research, Nationwide Children’s Hospital, Columbus, OH, United States

The 3D FLASH sequence is frequently used in structural imaging of the brain. Tissue contrast inhomogeneity, resulting from inhomogeneous transmit field and receiver sensitivity, significantly affects quantitative structural brain analyses such as classification and quantification of brain tissues in voxel-based morphometry and detection of pathological brain changes in clinical studies. It is important to optimize the sequence to jointly improve contrast efficiency and image homogeneity. In this work, we propose optimal imaging parameters and present methods to improve contrast efficiency and reduce or eliminate image inhomogeneity.

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