Abstract #1386

Normalization of Multi-contrast MRI and Prediction of Tumor Phenotypes

Yong Ik Jeong¹, Charles Cantrell¹, David Manglano¹, Thomas Gallagher¹, Jeffery Raizer¹, Craig Horbinski¹, and Timothy J Carroll¹

¹Northwestern University, Chicago, IL, United States

Genetic profiling of cancers has the potential to identify epigenetic changes that predict response to treatments. In this study, we try to overcome the limitations posed by heterogeneity of tumor phenotypes by using normalized quantitative MRI to predict local gene expression. We report the findings of retrospectively comparing T1, T1 post Gd, T2 and ADC to Verhaak subtypes and pMGMT methylation status in histologically confirmed GBM patients.

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