Abstract #1387

Intra- and inter-individual association of FET-PET- and MR-Perfusion-parameters in untreated glioma

Jens Goettler¹, Anne Kluge¹, Mathias Lukas², Stephan Kaczmarz¹, Jens Gempt³, Florian Ringel³, Mona Mustafa², Markus Schwaiger², Claus Zimmer¹, Stefan Foerster², Christine Preibisch^1,4, and Thomas Pyka²

¹Department of Neuroradiology, Technische Universität München, Munich, Germany, ²Clinic for Nuclear Medicine, Technische Universität München, Munich, Germany, ³Clinic for Neurosurgery, Technische Universität München, Munich, Germany, ⁴Clinic for Neurology, Technische Universität München, Munich, Germany

¹⁸F-fluoroethyltyrosine (FET) PET and dynamic susceptibility contrast (DSC) perfusion weighted imaging are useful imaging techniques to diagnose glioma and to delineate tumor extension. However it is still unclear whether static and dynamic parameters of FET-PET and DSC are associated with each other. In this study we examined 45 patients with glioma in a hybrid PET-MR 3T scanner assessing FET time-activity-curves and DSC-parameters simultaneously. Static as well as dynamic PET-measures highly correlated with DSC-parameters such as relative cerebral blood volume (rCBV) and relative peak height (rPH). Results point to a complementary role of both modalities pre-therapeutically.

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