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Abstract #1388

Estimating damage to the blood-brain barrier from radiotherapy treatment

Magne Kleppestø1, Christopher Larsson1, and Atle Bjornerud1,2

1The Intervention Centre, Oslo University Hospital, Oslo, Norway, 2Department of Physics, University of Oslo, Oslo, Norway

Brain tumors are usually subjected to radiation therapy upon diagnosis. In this work, it is made an attempt at investigating if this therapy might cause injury to the non-cancerous parts of the brain. To this end dynamic contrast-enhanced MRI was used to estimate leakage across the blood-brain barrier.22 patients were imaged before and after undergoing a treatment schedule, and findings from the two examinations were compared to uncover any change. The data shows no significant variation in either permeability or blood plasma volume.

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