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Abstract #1482

Dictionary based approach for accelerated determination of Pharmacokinetic maps using Partial Least Square regression

Nithin N Vajuvalli1, Shivaprasad Ashok Chikop1, and Sairam Geethanath1

1Medical Imaging Research Centre, Dayananda Sagar Institutions, Bangalore, India

This study is of relevance to MR researchers interested in DCE-MRI. Tofts model is a well-established two compartment model to determine the PharmacoKinetic (PK) maps, which is time consuming due to the presence of iterative curve fitting for each voxel. Current work focuses on the application of Partial Least Square (PLS) regression modelling to determine PK maps. PLS is a statistical method based on PCA and linear regression that provides the relationship between the predictor and response variables. We report 95-98% reduction in time as compared to curve fitting approaches for in silico phantoms and in vivo breast DCE data.

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