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Abstract #1483

Reproducibility and Variability of a Look-Locker FAIR ASL Sequence for Quantitative Measurement of Myocardial Blood Flow in Healthy Human Volunteers at 3T

Graeme A Keith1, Christopher T Rodgers1, Michael A Chappell2, and Matthew D Robson1

1Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

A previously presented arterial spin labelling (ASL) method was tested for reproducibility and variability. These measures are important to consider when planning a clinical study. The results presented show that the method has the sensitivity required to detect changes in MBF in pathology and under stress. The variation in individuals is shown to be less than across the sample as a whole. This knowledge will be useful in the planning of future clinical research studies.

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