Abstract #1484

T2 Relaxation of Human Blood at 3T Revisited: In Vivo and In Vitro Meaurement using TRUST MRI

Adam Bush¹, Jon Detterich², Thomas Coates³, Herbert Meiselman⁴, and John Wood¹

¹Biomedical Engineering/ Cardiology, University of Southern California/ Children's Hospital Los Angeles, Los Angeles, CA, United States, ²Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³Hematology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁴Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States

Precise knowledge of the T2 of blood (T2b) is required for spin-echo based blood oxygenation determination methods such as TRUST (T2 Relaxation Under Spin Tagging). In this study we measure the T2b in vivo and vitro using TRUST MRI. After correcting for physiologic variable we found that our model of T2b is statistically significantly different from the models used by other groups. We conclude those model lead to errors in derived parameters including oxygen saturation, oxygen extraction fraction and cerebral metabolic rate.

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