Fast Chemical Exchange Saturation Transfer (CEST) Imaging with Variably-accelerated Sensitivity Encoding (vSENSE)
Yi Zhang1, Hye-Young Heo1, Dong-Hoon Lee1, Paul Bottomley1, and Jinyuan Zhou1,2
1Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
CEST imaging has numerous applications, but its widespread clinical use
is hampered by relatively long acquisition times. Here, a novel
variably-accelerated sensitivity encoding (vSENSE) method is proposed that
provides faster CEST acquisitions than conventional SENSE. The vSENSE approach undersamples k-space
variably for images acquired at different saturation frequencies to maximize
acquisition speed. vSENSE was validated in a phantom and in 8 patients with brain tumors studied at
3T. The vSENSE method provided a 4-fold acceleration, compared to conventional
SENSE which permitted only a 2-fold acceleration, with both compared to a full
k-space reconstruction.
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