Abstract #1522

Fast Chemical Exchange Saturation Transfer (CEST) Imaging with Variably-accelerated Sensitivity Encoding (vSENSE)

Yi Zhang¹, Hye-Young Heo¹, Dong-Hoon Lee¹, Paul Bottomley¹, and Jinyuan Zhou^1,2

¹Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

CEST imaging has numerous applications, but its widespread clinical use is hampered by relatively long acquisition times. Here, a novel variably-accelerated sensitivity encoding (vSENSE) method is proposed that provides faster CEST acquisitions than conventional SENSE. The vSENSE approach undersamples k-space variably for images acquired at different saturation frequencies to maximize acquisition speed. vSENSE was validated in a phantom and in 8 patients with brain tumors studied at 3T. The vSENSE method provided a 4-fold acceleration, compared to conventional SENSE which permitted only a 2-fold acceleration, with both compared to a full k-space reconstruction.

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