Abstract #1601

Monitoring therapeutic response in anatomy and functions on pulmonary fibrosis by ultra-short echo time (UTE) MRI in an orthotopic mouse model

Masaya Takahashi¹, Keisuke Ishimatsu¹, Shanrong Zhang¹, Hua Lu², and Connie C.W. Hsia²

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States

The purpose of this study was to investigate the ability of in vivo ultra-short echo time (UTE)-MRI for assessment of pulmonary microstructure and functions of ventilation-perfusion in an animal model of pulmonary fibrosis in comparison with high-resolution MRI, physiological global measures and histomorphology.

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