Abstract #1691

Altered amplitude of low-frequency fluctuations and connectivities in depressed SAPHO syndrome

Jie Lu¹, Yan-ping Duan², Wen-rui Xu¹, Xue-wei Zhang³, Chen Li⁴, and Wei-hong Zhang¹

¹Department of Radiology, Peking Uinon Medical College Hospital, Beijing, China, People's Republic of, ²Department of Psychology, Peking Uinon Medical College Hospital, Beijing, China, People's Republic of, ³Department of interventional radiology, China Meitan General Hospital, Beijing, China, People's Republic of, ⁴Traditional Chinese Medicine Department, Peking Uinon Medical College Hospital, Beijing, China, People's Republic of

To investigate depressed symptoms in SAPHO（Synovitis, acne, pustulosis, hyperostosis, osteitis ） syndrome and confirm depression in SAPHO using resting-state functional magnetic resonance imaging (rs-fMRI). We recruited twenty-four SAPHO patients and fifteen age- and gender-matched normal controls (NC). Twelve of the SAPHO patients were diagnosed with depression. Moreover, depressed SAPHO patients (D-SAPHO) were proved to have abnormal amplitude of low frequency fluctuations (ALFF) and functional connectivities (FC) involved in the regional brain changes which showed correlated with the severity of depression. These findings provide crucial information to understand the neural mechanisms of depressed SAPHO and are helpful to diagnose depression in SAPHO.

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