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Abstract #1945

Increasing the Spatial Resolution and Sensitivity of High-Resolution Magnetic Resonance Elastography by Correcting for Subject Motion and Susceptibility-Induced Image Distortions

Andreas Fehlner1, Sebastian Hirsch1, Mykola Kadobianskyi2, Patric Birr1, Eric Barnhill1,3, Martin Weygandt2,4, Johannes Bernarding5, Jürgen Braun6, Ingolf Sack1, and Stefan Hetzer2,4

1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Clinical Research Imaging Centre, School of Clinical Sciences and Community Health, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom, 4Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany, 5Institut für Biometrie und Medizinische Informatik, Universitätsklinikum Magdeburg, Magdeburg, Germany, 6Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

High-resolution Multifrequency MR Elastography (MMRE) is hampered by susceptibility-induced image distortions. We corrected MMRE data of a 3T and 7T MR scanner for motion and EPI distortion artefacts. The correction of subject motion significantly sharpened the images, which was demonstrated by a decrease of the point-spread function. The improvement was highly correlated with the degree of subject motion. Distortion correction enhanced the accuracy of normalization in the MNI152 space as shown by an increase of the correlation between individual and standard tissue probability maps. This method could help increasing the sensitivity of multi-subject studies exploring |G*| e.g. in small subcortical areas.

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