Abstract #1945

Increasing the Spatial Resolution and Sensitivity of High-Resolution Magnetic Resonance Elastography by Correcting for Subject Motion and Susceptibility-Induced Image Distortions

Andreas Fehlner¹, Sebastian Hirsch¹, Mykola Kadobianskyi², Patric Birr¹, Eric Barnhill^1,3, Martin Weygandt^2,4, Johannes Bernarding⁵, Jürgen Braun⁶, Ingolf Sack¹, and Stefan Hetzer^2,4

¹Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Clinical Research Imaging Centre, School of Clinical Sciences and Community Health, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom, ⁴Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany, ⁵Institut für Biometrie und Medizinische Informatik, Universitätsklinikum Magdeburg, Magdeburg, Germany, ⁶Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

High-resolution Multifrequency MR Elastography (MMRE) is hampered by susceptibility-induced image distortions. We corrected MMRE data of a 3T and 7T MR scanner for motion and EPI distortion artefacts. The correction of subject motion significantly sharpened the images, which was demonstrated by a decrease of the point-spread function. The improvement was highly correlated with the degree of subject motion. Distortion correction enhanced the accuracy of normalization in the MNI152 space as shown by an increase of the correlation between individual and standard tissue probability maps. This method could help increasing the sensitivity of multi-subject studies exploring |G*| e.g. in small subcortical areas.

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