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Abstract #1947

Reproducibility of low-frequency MR elastography of the human brain

Florian Dittmann1, Sebastian Hirsch1, Jing Guo1, Jürgen Braun2, and Ingolf Sack1

1Institute of Radiology, Charité, Berlin, Germany, 2Department of Medical Informatics, Charité, Berlin, Germany

Since shear waves at low drive frequencies are nearly unaffected by attenuation, we introduce a brain MRE setup, which is based on remote excitation of intracranial shear waves by a pressurized-air actuator in the regime of 20 Hz. MRE-scans, which were repeated 27 times on three different days for each of six healthy volunteers, show differences between individuals as well as from day-to-day for the same individual. The investigation demonstrates that cerebral low frequency MRE provides a fast and reproducible novel source of mechanical information of brain tissue with less onerous head stimulation as required by conventional MRE.

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