Abstract #1947

Reproducibility of low-frequency MR elastography of the human brain

Florian Dittmann¹, Sebastian Hirsch¹, Jing Guo¹, Jürgen Braun², and Ingolf Sack¹

¹Institute of Radiology, Charité, Berlin, Germany, ²Department of Medical Informatics, Charité, Berlin, Germany

Since shear waves at low drive frequencies are nearly unaffected by attenuation, we introduce a brain MRE setup, which is based on remote excitation of intracranial shear waves by a pressurized-air actuator in the regime of 20 Hz. MRE-scans, which were repeated 27 times on three different days for each of six healthy volunteers, show differences between individuals as well as from day-to-day for the same individual. The investigation demonstrates that cerebral low frequency MRE provides a fast and reproducible novel source of mechanical information of brain tissue with less onerous head stimulation as required by conventional MRE.

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